Michael M. Gottesman

Michael M. Gottesman (born October 7, 1946 in Jersey City, New Jersey[1]) is an American biochemist, the Deputy Director (Intramural) of the National Institutes of Health (NIH) in the United States, and also Chief of the Laboratory of Cell Biology at the National Cancer Institute (NCI) within the NIH.[2] He graduated summa cum laude in biochemical sciences in 1966 from Harvard College, and received his M.D. magna cum laude from Harvard Medical School in 1970.[1] He then worked as an intern and resident at the Peter Dent Brigham Hospital in Boston, a research associate at the NIH, and an assistant professor at Harvard before taking a permanent position at the NIH in 1976.[1]

His areas of expertise includes a major contribution to the discovery of P-glycoprotein (MDR1, ABCB1), the multidrug resistance efflux transporter associated with clinical resistance to anti-cancer agents.[3][4] In 2007, he reported for the first time in Science magazine that silent polymorphisms can impact on the tertiary structure and function of a protein.[5]

He has been a Fellow of the American Association for the Advancement of Science since 1988.[1]

References

  1. ^ a b c d Biography as a speaker at the 1999 Conference on Biologic and Molecular Mechanisms for Sex Differences in Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics, Office of Research on Women's Health, retrieved 2010-02-28.
  2. ^ Staff profile, NCI, retrieved 2010-02-28.
  3. ^ Chen, Chang-jie; Chin, Janice E.; Ueda, Kazumitsu; Clark, Douglas P.; Pastan, Ira; Gottesman, Michael M.; Roninson, Igor B. (1986), "Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells", Cell 47 (3): 381–389, doi:10.1016/0092-8674(86)90595-7, PMID 2876781 .
  4. ^ Thiebaut, F.; Tsuruo, T.; Hamada, H.; Gottesman, M. M.; Pastan, I.; Willingham, M. C. (1987), "Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues", Proceedings of the National Academy of Sciences 84 (21): 7735–7738, doi:10.1073/pnas.84.21.7735, PMC 299375, PMID 2444983, http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=299375 .
  5. ^ Kimchi-Sarfaty, Chava; Oh, Jung Mi; Kim, In-Wha; Sauna, Zuben E.; Calcagno, Anna Maria; Ambudkar, Suresh V.; Gottesman, Michael M. (2007), "A "silent" polymorphism in the MDR1 gene changes substrate specificity", Science 315 (5811): 525–528, doi:10.1126/science.1135308, PMID 17185560 .

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